Alex T. Radosevich

Alex T. Radosevich

Main Content

  • Assistant Professor of Chemistry
Office:
520 Chemistry Building
University Park, PA 16802
Email:
(814) 867-4268

Education:

  1. B.S., University of Notre Dame, 2002
  2. Ph.D., University of California, Berkeley, 2007
  3. Postdoc, Massachusetts Institute of Technology, 2007-2010

Honors and Awards:

  1. ChevronTexaco Graduate Fellowship 2005
  2. NIH Ruth L. Kirschstein NRSA Postdoctoral Fellow 2007-2010
  3. NSF Career Award 2014
  4. Alfred P. Sloan Foundation Research Fellow 2014

Selected Publications:

McCarthy, S.M.; Lin, Y.-C.; Devarajan, D.; Chang, J.-W.; Yennawar, H.; Rioux, R.M.; Ess, D.H.; Radosevich, A.T. “Intermolecular N-H Oxidative Addition of Ammonia, Alkylamines, and Arylamines to a Planar σ3-Phosphorus Compound via an Entropy-Controlled Electrophilic Mechanism.” J. Am. Chem. Soc. 2014, doi: 10.1021/ja412469e.

Reichl, K.D; Ess, D.H.; Radosevich, A.T. “Catalyzing Pyramidal Inversion: Configurational Lability of P-Stereogenic Phosphines via Single Electron Oxidation.” J. Am. Chem. Soc. 2013, 135, 9354.

Zhao, W.; Fink, D.M.; Labutta, C.A.; Radosevich, A.T. “A Csp3–Csp3 Bond Forming Reductive Condensation of α-Keto Esters and Enolizable Carbon Pronucleophiles.” Org. Lett. 2013, 15, 3090.

Sathe, A.A.; Hartline, D.R.; Radosevich, A.T. “A Synthesis of α-Amino Acids via Direct Reductive Carboxylation of Imines with Carbon Dioxide.” Chem. Comm. 2013, 49, 5040.

Wang, S.R.; Radosevich, A.T. “Reductive Homocondensation of Benzylidene- and Alkylidenepyruvate Esters by a P(NMe2)3-Mediated Tandem Reaction.” Org. Lett. 2013, 15, 1926.

Miller, E.J.; Zhao, W.; Herr, J.D.; Radosevich, A.T. “A Nonmetal Approach to α- Heterofunctionalized Carbonyl Derivatives by Formal Reductive X-H Insertion.” Angew. Chem. Int. Ed. 2012, 51, 10605.

Dunn, N.L.; Radosevich, A.T. “Main Group Redox Catalysis: Reversible P(III)/P(V) Redox Cycling at a Phosphorus Platform.” J. Am. Chem. Soc. 2012, 134, 11330.

 

Information:

My research group is interested in developing new catalysts, synthetic strategies, and reagents for useful redox transformations. This broad goal will be realized in two distinct contexts: 1) the development of catalytic methods relevant to stereoselective organic synthesis, and 2) the catalytic reduction of substrates related to energy conversion. The projects we choose to pursue in the group are motivated by both a fundamental, mechanistic interest in redox reaction chemistry, as well as a very practical need for new, efficient and environmentally-friendly processes.

Students and post-doctoral researchers joining the group can expect to develop a range of synthetic skills spanning organic, inorganic, and organometallic subdisciplines. This synthetic expertise will be coupled with training in the rigorous characterization of new compounds via NMR, UV-Vis, IR, EPR, X-ray diffraction, and electrochemistry. By defining key structure-function relationships in this way, new catalysts with exciting and useful reactivites are anticipated.