Gong Chen

Gong Chen

Main Content

  • Associate Professor of Chemistry
433 Chemistry Building
University Park, PA 16802
(814) 867-2590

Selected Publications:

1.Pd-Catalyzed Mono-Selective ortho-C-H Alkylation of N-Quinolyl Benzamides: Evidence for Stereo-Retentive Coupling of Secondary Alkyl Iodides. Shuyu Zhang, Quiong Li, Gang He, William A. Nack, and Gong Chen. J. Am. Chem. Soc. 2015, 137, 531-539.

2. Palladium-Catalyzed Trifluoracetate-Promoted Mono-Arylation of β Methyl Group of Alanine at Room Temperature: Synthesis of β-Arylated α-Amino Acids through Sequential C-H Functionalization. Bo Wang, William A. Nack, Gang He, Shuyu Zhang, and Gong ChenChem. Sci. 2014, 5, 3952-3957.

3. Use of Readily Removable Auxiliary Group for the Synthesis of Pyrrolidones by the Palladium-Catalyzed Intramolecular Amination of UNactivated gC(sp3)-H Bonds. Gang He, Shuyu Zhang, William A. Nack, and Gong Chen. Angew. Chem., Int. Ed., 2013, 52, 11124-111128.

4. Palladium-Catalyzed Picolinamide-Directed Alkylation of Unactivated C(sp3)-H Bonds with Alkyl Iodides.  Shu-Yu Zhang, Gang He, William A. Nack, Yingsheng Zhao, Qiong Li, and Gong Chen.  J. Am. Chem. Soc. 2013, 135, 2124-2127.

5. Anticancer PAD Inhibitors Regulate the Autophagy Flux and the Mammalian Target of Rapamycin Complex 1 Activity. Wang, Y.J., Li, P., Wang, S., Hu, J., Fisher, M., Oshaben, K., Wu, J., Zhao, N., Wang, D., Chen, G., Wang, Y. J. Biol. Chem. 2012, 287, 25941-25953.

6. Highly Efficient Syntheses of Azetidines, Pyrrolidines and Indolines via Palladium-Catalyzed Intramolecular Amination of C(sp3) and C(sp2)-H Bonds at g and d Positions. Gang He, Yingsheng Zhao, Shuyu Zhang, Chengxi Lu, and Gong Chen. J. Am. Chem. Soc. 2012, 134, 3-6.

7. Chemical Synthesis of Bis-phosphorylated Mannose-6-Phosphate N-Glycan and its Facile Mono-Conjugation with Human Carbonic Anydrase II for in vivo Flourescence Imaging. Yupeng Liu, Yan M Chan, Jianhui Wu, Chen Chen, Alan Benesi, Jing Hu, Yanming Wang, and Gong Chen. Chem. Bio. Chem. 2011, 12, 685-690.

8. Total Synthesis of Celogentin C via Stereoselective C-H Activation. Yiqing Feng and Gong Chen. Angew. Chem., Int. Ed. 2010, 49, 958-961.


Our laboratory is interested in developing new anti-bacterial and anti-cancer drugs.

Our group is interested in synthetic and biological studies of complex peptides and carbohydrates. Our current research projects include developing new synthetic methods for amino acid synthesis, total synthesis of complex peptide natural products, and studying the biological functions of mannose-6-phosphate-containing /N/-glycans.

Research Interests:


Fluorescence imaging of protein trafficking in live cells


Chemical biology of carbohydrates and peptides

Materials and Nanoscience

Nano material for molecular imaging in live cells


Synthetic and biological studies of carbohydrates and peptides

Chemical Biology