Joseph Cotruvo

Joseph Cotruvo

Main Content

  • Assistant Professor of Chemistry
  • Louis Martarano Career Development Professor
Office:
220 Chemistry Building
University Park, PA 16802
Email:
(814) 863-4869

Mailing Address:
104 Chemistry Building

Education:

  1. Ph.D., Chemistry, Massachusetts Institute of Technology, 2012
  2. A.B., Chemistry, Princeton University, 2006

Honors and Awards:

  1. Jane Coffin Childs Memorial Fund Postdoctoral Fellowship, 2013-2016
  2. National Defense Science and Engineering Graduate Fellowship, 2008-2011

Selected Publications:

Krishnamoorthy, L.,* Cotruvo, J.A., Jr.,* Chan, J., Kaluarachchi, H., Muchenditsi, A., Pendyala, V.S., Jia, S., Aron, A.T., Ackerman, C.M., Vander Wal, M.N., Guan, T., Smaga, L.P., Farhi, S.S., New, E.J., Lutsenko, S., and Chang, C.J. Copper regulates cyclic-AMP-dependent lipolysis. Nat. Chem. Biol., 2016, 12, 586-592.  (*Co-first authors)

Cotruvo, J.A., Jr., Aron, A.T., Ramos-Torres, K.M., and Chang, C.J.  Synthetic fluorescent probes for studying copper in biological systems.  Chem. Soc. Rev. 2015, 44, 4400-4414.

Cotruvo, J.A., Jr., Stich, T.A., Britt, R.D., and Stubbe, J.  Mechanism of assembly of the dimanganese-tyrosyl radical cofactor of class Ib ribonucleotide reductase: Enzymatic generation of superoxide is required for tyrosine oxidation
via a MnIIIMnIV intermediate.  J. Am. Chem. Soc. 2013, 135, 4027-4039.

Cotruvo, J.A., Jr. and Stubbe, J. Metallation and mismetallation of iron and manganese proteins in vitro and in vivo: the class I ribonucleotide reductases as a case study. Metallomics 2012, 4, 1020-1036.

Cotruvo, J.A., Jr. and Stubbe, J.  Class I ribonucleotide reductases: Metallocofactor assembly and repair in vitro and in vivo. Annu. Rev. Biochem. 2011, 80, 733-767.

Cotruvo, J.A., Jr. and Stubbe, J.  Escherichia coli class Ib ribonucleotide reductase contains a dimanganese(III)-tyrosyl radical cofactor in vivo.  Biochemistry 2011, 50, 1672-1681.

Boal, A.K., Cotruvo, J.A., Jr., Stubbe, J., and Rosenzweig, A.C.  Structural basis for activation of class Ib ribonucleotide reductase. Science 2010, 329, 1526-1530.

Cotruvo, J.A., Jr. and Stubbe, J.  An active dimanganese(III)-tyrosyl radical cofactor in Escherichia coli class Ib ribonucleotide reductase. Biochemistry 2010, 49, 1297-1309.

Cotruvo, J.A., Jr. and Stubbe, J.  NrdI, a flavodoxin involved in maintenance of the diferric-tyrosyl radical cofactor in Escherichia coli class Ib ribonucleotide reductase.  Proc. Natl. Acad. Sci. U.S.A. 2008, 105, 14383-14388.

Research Interests:

Biological

Chemical biology of metal ion and redox homeostasis

Inorganic

Chemical biology of metal ion and redox homeostasis