Mark Hedglin

Mark Hedglin

Main Content

  • Assistant Professor of Chemistry and the Huck Institute of the Life Sciences
  • Assistant Professor of Biochemistry and Molecular Biology, College of Medicine
210A Wartik Lab
University Park, PA 16802
(814) 863-1080


  1. Ph.D., Chemical Biology, University of Michigan, 2010
  2. B.A., Biochemistry, Ithaca College, 2005

Honors and Awards:

  1. NIH Ruth L. Kirschstein NRSA Postdoctoral Fellowship, 2012 – 2015

Selected Publications:

Hedglin, M., Aitha M., and Benkovic, S.J. Monitoring the Retention of Human PCNA at Primer/Template junctions by Proteins that Bind Single-stranded DNA. Biochemistry, 2017, 56, 3415 – 3421.

Hedglin, M. and Benkovic, S.J. Eukaryotic Translesion DNA Synthesis on the Leading and Lagging Strands: Unique Detours Around the Same Obstacle. 2017, ACS Chemical Reviews, 117, 7857 – 7877.

Hedglin, M. and Benkovic, S.J. Replication protein A prohibits diffusion of the PCNA sliding clamp along single-stranded DNA. Biochemistry, 2017, 56, 1824 – 1835.

Hedglin, M., Pandey, B., and Benkovic, S.J. Characterization of human translesion DNA synthesis across a UV-induced DNA lesion. 2016, eLife 5, e19788.

Hedglin, M., Pandey, P., and Benkovic, S.J. Stability of the human polymerase δ holoenzyme and its implications in lagging strand DNA synthesis. 2016, Proc Natl Acad Sci U S A, 113, E1777 - E1786.

Hedglin, M., Zhang, Y., and O'Brien, P.J. Probing the DNA structural requirements for facilitated diffusion. Biochemistry, 2015, 54, 557-566.

Hedglin, M., and Benkovic, S.J. Regulation of Rad6/Rad18 Activity During DNA Damage Tolerance. Annu Rev Biophys, 2015, 44, 207-228.

Hedglin, M., Zhang, Y., and O'Brien, P.J. Isolating contributions from intersegmental transfer to DNA searching by alkyladenine DNA glycosylase. J Biol Chem, 2013, 288, 24550-24559.

Hedglin, M., Perumal, S.K., Hu, Z., and Benkovic, S. Stepwise assembly of the human replicative polymerase holoenzyme. eLife, 2013, 2, e00278.

Hedglin, M., Kumar, R., and Benkovic, S.J. Replication clamps and clamp loaders. Cold Spring Harb Perspect Biol, 2013, 5, a010165.

Hedglin, M., and O'Brien, P.J. Hopping enables a DNA repair glycosylase to search both strands and bypass a bound protein. ACS Chem Biol, 2010, 5, 427-436.

Hedglin, M., and O'Brien, P.J. Human alkyladenine DNA glycosylase employs a processive search for DNA damage. Biochemistry, 2008, 47, 11434-11445.

Krennhrubec, K., Marshall, B.L., Hedglin, M., Verdin, E., and Ulrich, S.M. Design and evaluation of 'Linkerless' hydroxamic acids as selective HDAC8 inhibitors. Bioorg Med Chem Lett, 2007, 17, 2874-2878.