Independent Work at Penn State
Y. Liu, K. Miao, N.P. Dunham, H. Liu, M. Fares, X. Li, A.B. Boal, X. Zhang, The cation-pi interaction enables a Halo-Tag fluorogenic probe for fast no-wash live cell imaging and gel-free protein quantification, Biochemistry, (2017), DOI: 10.1021/acs.biochem.7b00056
Prior to Penn State
Y. Liu*, X. Zhang*, W.T. Chen, Y.L. Tan, J.W. Kelly, “Fluorescence turn-on folding sensor to monitor proteome stress in live cells”, J Am Chem Soc, 137 (2015), 11303-11321, (*co-first authors).
Y.H. Cho*, X. Zhang*, Y. Liu, K. Fayer, D.L. Powers, J.W. Kelly, L. Gierasch. E.T. Powers, “Individual and collective contributions of chaperonin and degradation to protein homeostasis in E. coli”, Cell Reports, 11 (2015), 321-33, (*co-first authors).
Y. Liu*, Y.L. Tan*, X. Zhang*#, G. Bhabha, D. Ekiert, J.C. Genereux, Y.H. Cho, Y. Kipnis, D. Baker, J.W. Kelly#, “Small molecule probes to quantify the functional fraction of a specific protein in a cell with minimal folding equilibrium shifts”, Proc Natl Acad Sci (USA), 111 (2014), 4449-54, (*co-first authors listed alphabetically; #co-corresponding authors).
X. Zhang, Y. Liu, J.C. Genereux, C. Nolan, M. Singh, J.W. Kelly, “The heat-shock response transcriptional program enables high-yield and high-quality recombinant protein production in Escherichia coli”, ACS Chem Biol, 9 (2014), 1945-1949.
Y. Liu*, X. Zhang*, Y.L. Tan, G. Bhabha, D. Ekiert, D. Baker, J.W. Kelly, “De novo designed enzymes as small molecule-regulated fluorescence imaging tags and fluorescent reporters”, J Am Chem Soc, 136 (2014), 13102-13105, (*co-first authors).
X. Zhang and J.W. Kelly, “Chaperonins resculpt folding free energy landscapes to avoid kinetic traps and accelerate protein folding” J Mol Biol, 426 (2014), 2736-8.
X. Zhang and S. Shan, “Fidelity of co-translational protein targeting by the signal recognition particle”, Ann Rev Biophysics, 43 (2014), 381-408.
D. Akopian*, K. Shen*, X. Zhang*, S. Shan, “Signal recognition particle: An essential targeting machine”, Ann Rev Biochemistry, 82 (2013), 693-722 (*co-first authors listed alphabetically).
X. Zhang, V.Q. Lam, Y. Mou, T. Kimura, J. Chung, S. Chandrasekar, J.R. Winkler, S.L. Mayo, S. Shan, “Direct visualization reveals dynamics of a transient intermediate during protein assembly”, Proc Natl Acad Sci (USA), 108 (2011), 6450-55.
X. Zhang, R. Rashid, K. Wang, and S. Shan, “Sequential checkpoints govern substrate selection during co-translational protein targeting”, Science, 328 (2010), 757-60.
X. Zhang, C. Schaffitzel, N. Ban, and S. Shan, “Multiple conformational switches in a GTPase complex control co-translational protein targeting”, Proc Natl Acad Sci (USA), 106 (2009), 1754-59.
X. Zhang, S. Kung and S. Shan, “Demonstration of a multistep mechanism for assembly of the SRP•SRP receptor complex: Implications for the catalytic role of SRP RNA”, J Mol Biol, 381 (2008), 581-93.