Eric Nacsa

Eric Nacsa

Main Content

  • Assistant Professor of Chemistry
426 Chemistry Building
University Park, PA 16802
(814) 863-1339

Mailing Address:
104 Chemistry Building
University Park, PA 16802


  1. Postdoctoral Research, Princeton University
  2. PhD, Columbia University, 2015
  3. BSc, Harvey Mudd College, 2010

Honors and Awards:

  1. NIH Ruth L. Kirschstein NRSA Postdoctoral Fellowship, 2017-2019
  2. Arun Guthikonda Memorial Graduate Fellowship, Columbia University, 2013
  3. ACS Division of Polymer Chemistry Award, 2010
  4. Harvey S. Mudd Merit Scholarship, Harvey Mudd College, 2006-2010

Selected Publications:

Nacsa, E. D.; MacMillan, D. W. C. “Spin-Center Shift-Enabled Direct Enantioselective α-Benzylation of Aldehydes with Alcohols.” J. Am. Chem. Soc. 2018140, 3322–3330.

Nacsa, E. D.; Lambert, T. H. “Cross-Coupling of Sulfonic Acid derivatives via Aryl-Radical Transfer (ART) Using TTMSS or Photoredox.” Org. Chem. Front. 20185, 64–69.

Nacsa, E. D.; Lambert, T. H. “Higher-Order Cyclopropenimine Superbases. Direct Neutral Brønsted Base Catalyzed Michael Reactions with α-Aryl Esters.” J. Am. Chem. Soc. 2015137, 10246–10253.

An, J.; Denton, R. M.; Lambert, T. H.; Nacsa, E. D. “The Development of Catalytic Nucleophilic Substitution Reactions: Challenges, Progress and Future Directions.” Org. Biomol. Chem. 201412, 2993–3003.

Nacsa, E. D.; Lambert, T. H. “Cyclopropenone Catalyzed Inversion of Alcohols with Mesylate Ion.” Org. Lett. 201315, 38–41.


Our group is primarily interested in addressing important challenges in synthetic organic chemistry. In particular, we will seek new, general strategies to prepare complex, biologically active compounds or substructures from the simplest possible feedstocks. This work will involve designing new reactions, catalysts, and reagents, and will be driven by mechanistic hypotheses and investigations. Furthermore, we will seek to harness new reactivity principles in organic chemistry to develop enabling tools for chemical biology, identify scalable approaches to renewable organic feedstocks, and prepare organic polymers with improved functionality.