Ramesh Giri

Ramesh Giri

Main Content

  • Weinreb Early Career Professor
Office:
433 Chemistry Building
University Park, PA 16802
Email:
(814) 865-0063

Mailing Address:
104 Chemistry Building
University Park, PA 16802

Education:

  1. Postdoc., University of California,
  2. Berkeley/University of Illinois Urbana-Champaign, 2012
  3. PhD, The Scripps Research Institute, 2009
  4. MPhil, University of Cambridge, UK 2003
  5. MSc, Tribhuvan University, Nepal 1998

Honors and Awards:

  1. National Science Foundation (NSF) CAREER Award, 2016
  2. Theme Chemistry Journals Award, 2016
  3. Myron Rosenblum Endowed Fellowship, Brandeis University, 2006
  4. Cambridge Overseas Trust Scholarship, University of Cambridge, UK, 2002

Selected Publications:

Basnet, P.; KC, S.; Dhungana, R. K.; Shrestha, B.; Boyle, T. J.; Giri, R. "Synergistic Bimetallic Ni/Ag and Ni/Cu Catalysis for Regioselective g,d-Diarylation of Alkenyl Ketimines: Addressing b-H Elimination by in situ Generation of Cationic Ni(II)-Catalysts" J. Am. Chem. Soc. 2018 , 140, 15586–15590.

Gokhale, R.; Thapa, S.; Artyushkova, K.; Giri, R.; Atanassov, P. "Fully Synthetic Approach towards Transition Metal-Nitrogen-Oxygen Reduction Electrocatalysts" ACS Appl. Energ. Mater. 2018, 1, 3802–3806.

Basnet, P.; Dhungana, R. K.; Thapa, S.; Shrestha, B.; KC, S.; Sears, J. M.; Giri, R. "Ni-Catalyzed Regioselective b,d-diarylation of Unactivated Olefins in Ketimines via Ligand-Enabled Contraction of Transient Nickellacycles: Rapid Access to Remotely Diarylated Ketones" J. Am. Chem. Soc. 2018 , 140, 7782–7786.

Giri, R.; Brusoe, A.; Troshin, K.; Wang, J, Y.; Font, M.; Hartwig, J. F. "Mechanism of the Ullmann Biaryl Ether Synthesis Catalyzed by Complexes of Anionic Ligands: Evidence for the Reaction of Iodoarenes with Ligated Anionic CuI Intermediates" J. Am. Chem. Soc.2018, 140, 793–806.

Shrestha, B.; Basnet, P.; Dhungana, R. K.; KC, S.; Thapa, S.; Sears, J. M.; Giri, R. "Ni-Catalyzed Regioselective 1,2-Dicarbofunctionalization of Olefins by Intercepting Heck Intermediates as Imine-Stabilized Transient Metallacycles" J. Am. Chem. Soc. 2017 , 139, 10653–10656.

Thapa, S.; Kafle, A.; Gurung, S. K.; Montoya, A.; Riedel, P.; Giri, R. "Ligand-Free Copper-Catalyzed Negishi Coupling of Alkyl-, Aryl- and Alkynylzinc Reagents with Heteroaryl Iodides" Angew. Chem. Int. Ed. 201554, 8236-8240.

Giri, R.; Lan, Yu.; Liu, P.; Houk, K. N.; Yu, J.-Q. “Understanding Reactivity and Stereoselectivity in Palladium-
Catalyzed Diastereoselective sp3 C–H Bond Activation: Intermediate Characterization and Computational Studies” J. Am. Chem. Soc. 2012, 134, 14118.

Giri, R.; Yu, J.-Q. “Synthesis of 1,2-and 1,3-Dicarboxylic Acids via Pd(II)-Catalyzed Carboxylation of Aryl and Vinyl C–H Bonds” J. Am. Chem. Soc. 2008, 130, 14082.

Giri, R.; Maugel, N.; Li, J.-J.; Wang, D.-H; Breazzano, S. P.; Saunders, L. B.; Yu, J.-Q. “Palladium-Catalyzed Methylation and Arylation of sp2 and sp3 C–H Bonds in Simple Carboxylic Acids” J. Am. Chem. Soc. 2007, 129, 3510.

Giri, R.; Chen, X.; Yu, J.-Q. “Palladium-Catalyzed Asymmetric Iodination of Unactivated C–H Bonds under Mild Conditions” Angew. Chem., Int. Ed. 2005, 44, 2112.

Information:

The Giri lab works at the interface of organic, organometallic, inorganic and material chemistry, and is interested in developing novel organic reactions and materials based on the first row late transition metals (Fe, Co, Ni and Cu). These reactions and materials have extensive applications in areas ranging from the development of new materials, renewable fuels and electrocatalysts, and diversification of existing drugs to the step-economic and cost-effective synthesis of complex molecules, natural products and pharmaceuticals. Our research is currently tailored to develop new catalytic pathways for alkene difunctionalization, protodecarboxylation, decarboxylative functionalization, photoredox catalysis, C-H activation, fluorination and trifluoromethylation. Our group also synthesizes organometallic complexes that either function as intermediates to study reaction mechanisms or serve as electrocatalysts for fuel cell applications.