Mark Hedglin Joins Chemistry Faculty

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Mark Hedglin Joins Chemistry Faculty

The Chemistry Department is delighted to welcome Mark Hedglin as an assistant professor of Chemistry and the Huck Institute of the Life Sciences.

Hedglin also holds appointment as an assistant professor of Biochemistry and Molecular Biology at College of Medicine, Penn State. Before joining the faculty at Penn State he was a Research Associate and a postdoctoral fellow with Professor Stephen Benkovic at Penn State (2010-2017). Hedglin received his Ph.D. at the University of Michigan for Biological Chemistry in 2010 and B.S. at the Ithaca College for Chemistry in 2005. Hedglin’s awards include the Ruth L. Kirschstein National Research Service Award in 2012.

Hedglin’s research program lies in the intersection between biological chemistry, biophysical chemistry, and cell biology. His projects are focused on the essential process of DNA replication. In particular, he is interested in a multifunctional protein PCNA (proliferating cell nuclear antigen) that is present in the nuclei of eukaryotic cells. As a component of the DNA replication machinery, PCNA plays an important role in both DNA replication and repair. Hedglin’s research primarily answers how PCNA-binding interactions are regulated throughout the cell cycle and how these interactions are altered to accommodate and overcome replication stress. These questions will be addressed via a multi-disciplinary approach that combines mechanistic enzymology, biophysical chemistry, and cell biology. Because the proper regulation of PCNA is critical to the efficient and faithful replication of the genome, understanding these questions has important biomedical implications in a variety of cancers. Ultimately, these research accomplishments will lead to innovative cancer chemotherapeutics and treatment approaches.