Amie K. Boal

Amie K. Boal

Main Content

  • Assistant Professor of Chemistry
  • Assistant Professor of Biochemistry and Molecular Biology
Office:
326 Chemistry Building
University Park, PA 16802
Email:
(814) 867-2863

Education:

  1. Ph.D. Chemistry, California Institute of Technology, 2008
  2. B.A. Chemistry, Pomona College, 2002

Honors and Awards:

  1. Camille Dreyfus Teacher-Scholar Award, 2018
  2. NIH Pathway to Independence Award, 2012
  3. NIH Ruth L. Kirschstein NRSA Postdoctoral Fellowship, 2011-2012
  4. American Cancer Society Postdoctoral Fellowship, 2010-2011

Selected Publications:

Blaesi, E.J.*; Palowitch, G.M.*; Hu, K.*; Kim, A.J.; Rose, H.R.; Alapati, R.B.; Lougee, M.G.; Kee, H.J.; Taguchi, A.T.; Tan, K.O.; Griffin, R.G.; Krebs, C.; Matthews, M.L.; Silakov, A.; Bollinger, J.M., Jr.; Allen, B.D.; Boal, A.K. “Metal-free class Ie ribonucleotide reductase from pathogens initiates catalysis with a tyrosine-derived dihydroxyphenylalanine radical.” Proc. Natl. Acad. Sci. USA 2018. In press.

Rose, H.R.*; Ghosh, M.K.*; Maggiolo, A.O.; Pollock, C.J.; Blaesi, E.J.; Hajj, V.; Wei, Y.; Rajakovich, L.J.; Chang, W.-c.; Han, Y.; Hajj, M.; Pandelia, M.-E.; Krebs, C.; Bollinger, J.M., Jr.; Boal, A.K. “Structural basis for superoxide activation of Flavobacterium johnsoniae class I ribonucleotide reductase and for radical initiation by its dimanganese cofactor.” Biochemistry 2018, 57, 2679-2693.

Mitchell, A.J.*; Dunham, N.P.*; Martinie, R.J.; Bergman, J.A.; Pollock, C.J.; Hu, K.; Allen, B.D.; Chang, W.-c.; Silakov, A.; Bollinger, J.M., Jr.; Krebs, C.; Boal, A.K. “Visualizing the reaction cycle in an iron(II) and 2-(oxo)-glutarate-dependent hydroxlase.” J. Am. Chem. Soc. 2017, 139, 13830-13836.

Mitchell, A.J.; Dunham, N.P.; Bergman, J.A.; Wang, B.; Chang, W.-c. Liu, X.; Boal, A.K. “Structure-guided engineering of a small-molecule aliphatic halogenase.” Biochemistry 2017, 56, 441-444.

Mitchell, A.J.; Zhu, Q.; Maggiolo, A.O.; Ananth, N.; Hillwig, M.L.; Liu, X.; Boal, A.K. “Structural basis for selective chlorination by iron- and 2-oxo-glutarate-dependent WelO5.” Nat. Chem. Biol. 2016, 12, 636-640.

Schwalm, E.L.*; Grove, T.L.*; Booker, S.J.; Boal, A.K. “Crystallographic capture of a radical S-adenosylmethionine enzyme in the act of modifying tRNA.” Science 2016, 352, 309-312.

Boal, A. K., Grove, T. L., McLaughlin, M. I., Yennawar, N. H., Booker, S. J., and Rosenzweig, A. C. Structural basis for methyl transfer by a radical SAM enzyme. Science, 2011, 332, 1089-1092.

Boal, A. K., Cotruvo, J. A., Jr., Stubbe, J., and Rosenzweig, A. C. Structural basis for activation of class Ib ribonucleotide reductase. Science, 2010, 329, 1526-1530.

Boal, A. K., and Rosenzweig, A. C. Crystal structures of cisplatin bound to a human copper chaperone. J. Am. Chem. Soc., 2009, 131, 14196-14197.

Boal, A. K., Genereux, J. C., Sontz, P. A., Gralnick, J. A., Newman, D. K., and Barton, J. K. Redox signaling between DNA repair proteins for efficient lesion detection. Proc. Natl. Acad. Sci. USA, 2009, 106, 15237-15242.